TANDEM Technology and Engineering in Medicine

Health Technology

TANDEM, the competence center for medical technology in northern Germany, is a joint venture of the medical departments of the University of Lübeck, the Technische Hochschule Lübeck and the University Medical Center Schleswig-Holstein.
TANDEM combines basic research with application orientation and clinical know-how through broad expertise, many years of experience and close proximity. Our team works closely together in a friendly creative atmosphere. TANDEM aims to make the knowledge resulting from research, development and clinical studies available to companies.

From left to right: Prof. Dr. Philipp Rostalski (Project 3), Prof. Dr. Stephan Klein (Project 4), Dr. Ralf Brinkmann (Project 5), Prof. Dr. Thorsten Buzug (Project 1), Prof. Dr. Hartmut Gehring (Project 2) and Holger Fischer

TANDEM III  – Cross Innovation Center

The project Cross-Innovation-Center (CIC) – Tandem Phase III pursues the goal of substantially broadening the utilization basis of research and development work at the University of Lübeck and the Lübeck University of Applied Sciences through cross-innovation strategies.

Kerstin RönickTANDEM is managed by Holger Fischer, Head of Research and Transfer at the University of Lübeck, together with the project manager of TANDEM III Kerstin Rönick.

Their focus is on the exchange between the five following projects and their business partners. Furthermore, a Cross-Innovation-Center with different approaches should be developed. For instance, Storytelling about the potentials in medical engineering and health research from Lübeck, building networks for supporting prototype manufacturing or using new formats of events to work with companies together, trying out cross innovation and creating new research projects. The exchange with the Start-Up environment of the BioMedTec Science Campus Lübeck gets supported by questions in the medical engineering field and active networking with the research groups within the Cross-Innovation-Center.

Five very interesting different medical technology projects are working in TANDEM III together.


Project 1 | CT Image Reconstruction with Deep Learning

In this project iterative algorithms for artifact-free images within the computed tomography are developed at the Institute of Medical Engineering (IMT) together with the Fraunhofer IMTE (Institution for Individualized and Cell-Based Medical Engineering). The quality and diagnostic value of the images should be increased specifically from Patient with metal implants.

For further information, please contact:


Nele Blum, M.Sc.
Research assistant at the Institute of Medical Engineering
University of Lübeck


Project 2 | Optical and optoacoustic sensors for measuring the hemoglobin concentration

Optical and optoacoustic sensors for measuring the hemoglobin concentration

Hemoglobin is a fascinating molecule.

The binding, transport and release of oxygen from the lungs to the cell is ingeniously solved. Both molecule and function – are essential for human life and performance. This is what makes the amount of hemoglobin in the human body so valuable. And it is the reserve in case of an emergency, either in the event of a lack of oxygen or loss of hemoglobin.

These are the reasons for continuously monitoring the concentration of hemoglobin without harming a critically ill patient.

This is where the project starts. The aim is a sensor and a monitoring method for the non-invasive and continuous measurement of the hemoglobin concentration in critically ill people – for children and adults.

Mayda S, Kandemir Z, Bulut N, Maekawa S. Magnetic mechanism for the biological functioning of hemoglobin. Nature Scietific Reports 2020

For further information, please contact:


Prof. Dr. med. Hartmut Gehring
Clinic for Anesthesiology and Intensive Care Medicine
Senior Physician, Head of Diagnostics and Intervention Division

University Medical Center Schleswig-Holstein
Campus Lübeck
Ratzeburger Allee 160
23538 Lübeck


Project 3 | Model-based development, verification and approval of medical assistance systems

In this project, a concept for testing automated functions of medical devices is developed and implemented exemplarily for autonomous functions in mechanical ventilation. For this purpose, an ontology-based test approach is chosen and the tests are used for verification on system level. Thereby, the concept for the test system consists of two main components. First, a software for defining relevant test scenarios and second, a test bench for applying the relevant test scenarios.

For further information, please contact:


Sandra Henn, M. Sc.

Research Assistant
+49 451 3101 6225



Prof. Dr. Philipp Rostalski
Director of the Institute for Electrical Engineering in Medicine
+49 451 3101 6200


University of Lübeck
Moislinger Allee 53-55, Building 19
23558 Lübeck


Project 4 | Development and Validation of an In-Vitro-Model to Simulate the Transurethral Resection of Prostate Tissue

The transurethrale resection of the prostate (TUR-P) is considered the “gold standard” treatment of benign prostatic hyperplasia (BPH) that can no longer be controlled by drug therapy.

It comprises the iterative ablation of prostate tissue with an electrode at the tip of a resectoscope that is inserted through the patient’s penis. This process may entail a variety of complications, ranging from the perforation of the bladder to hypothermia. This project aims to provide an in-vitro-model that serves as a development environment for surgical instrument manufacturers and doctors and helps to comprehend the parameters that may affect said complications. The model will be used to foster progress in the improvement of the surgery. However, the proposed model will only serve its purpose upon completion of a successful validation. Moreover, a validated in-vitro-model has the potential to replace animal testing. Hence, a suitable validation method will be developed in course of this project.

For further information, please contact:



Max Ramien, M.Sc.
Research Assistant
+49 451 300 5518

Technische Hochschule Lübeck
University of Applied Sciences
Laboratory for Medical Sensor and Device Technology
Mönkhofer Weg 239, Building 64
23562 Lübeck



Project 5 | Optoacoustic measurement system for breath diagnostics

Concentration changes of different volatile organic compounds (VOCs) in breath indicate various diseases, such as infections or inflammations of the lungs. Photoacoustic spectroscopy can be used to detect specific VOCs – a sound wave is generated by modulated/pulsed optical excitation of the substances and heat generation by collisional deactivation. The focus of the work is the improvement of a photoacoustic measurement cell based on finite element simulations of the signal generation as well as the experimental realization and optimization of the method.

Furthermore, for the extension of the coverable wavelength range, a new excitation source (optical parametric oscillator) will be realized to improve the measurement method with respect to number and selectivity of detectable volatile organic compounds.

For further information, please contact:


Dr. Ralf Brinkmann
Institute of Biomedical Optics
+49 451 3101 3207


University of Lübeck
Peter-Monnik-Weg 4
23562 Lübeck